Introduction: Growing Interest in Orthobiologics
Interest in orthobiologics continues to grow in sports medicine.
In particular, physicians are evaluating platelet-rich plasma preparation and other biologic approaches for musculoskeletal care.
At the same time, clinical evidence continues to develop. Therefore, many physicians are seeking guidance on how to use these technologies responsibly.
What Are Orthobiologics?
Orthobiologics are biologic materials used in musculoskeletal medicine.
These may include:
• platelet-rich plasma (PRP)
• bone marrow-derived products
• other autologous biologic preparations
Clinicians often use a PRP preparation system to produce platelet-rich plasma from a patient’s own blood.
Because of this, platelet-rich plasma preparation remains one of the most widely studied orthobiologic approaches.
Why Guidance Matters in Regenerative Medicine
Although research is expanding, variability still exists.
For example, differences in:
• PRP preparation systems
• platelet concentration
• leukocyte levels
• clinical protocols
can influence outcomes.
Therefore, physicians need clear, evidence-based guidance when introducing orthobiologics into clinical practice.
AMSSM Position Statement: Key Highlights
The American Medical Society for Sports Medicine (AMSSM) developed a position statement to support responsible use of orthobiologics.
This guidance helps physicians better understand:
1. Standard Terminology
Clear definitions of orthobiologics, including platelet-rich plasma preparation, help reduce confusion.
2. Basic Science
The statement reviews how biologic materials interact with tissue and healing environments.
3. Clinical Research
It summarizes current studies on orthobiologics in sports medicine.
However, it also emphasizes the need for more standardized research.
4. Regulatory Considerations
The statement outlines important regulatory frameworks.
This includes guidance on how biologic products are classified and used in clinical settings.
5. Best Practices for Clinical Use
Finally, the AMSSM provides recommendations for:
• patient selection
• informed consent
• documentation
• clinical decision-making
How Physicians Can Apply These Guidelines
Physicians can use this guidance to evaluate orthobiologic technologies, including PRP preparation systems.
For example, clinicians may:
• review available scientific literature
• compare platelet-rich plasma preparation methods
• assess workflow integration
• ensure compliance with regulatory standards
As a result, practices can introduce orthobiologics more responsibly.
The Role of PRP Preparation Systems
Because platelet-rich plasma preparation is widely used, system selection matters.
Clinicians often evaluate:
• consistency of platelet concentration
• leukocyte profile
• red blood cell reduction
• reproducibility of preparation
Therefore, choosing the right PRP preparation system supports more consistent results and workflow efficiency.
Conclusion: Responsible Adoption of Orthobiologics
Orthobiologics represent a growing area in sports medicine.
However, responsible adoption is essential.
By following the AMSSM position statement, physicians can:
• make informed clinical decisions
• improve patient communication
• align with current best practices
As research continues, structured guidance will remain critical for integrating orthobiologics and platelet-rich plasma preparation into clinical care.
Learn More
👉 American Medical Society for Sports Medicine Position Statement:
Principles for the Responsible Use of Regenerative Medicine in Sports Medicine
Regulatory Notice
PRP preparation systems are intended for the preparation of autologous platelet-rich plasma.
Clinical use of orthobiologics is determined by the treating physician based on patient evaluation and professional judgment.
Statements regarding orthobiologics reflect published scientific literature and are not intended to imply FDA-cleared indications for specific clinical outcomes.